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Human Growth hormone administration within normal animals leads to muscle hypertrophy, but this muscular growth is not accompanied by increased strength ( but size definitely increased). We then looked at the effects of an anabolic steroid on weight gain, muscle strength, and muscle mass and found some interesting results.Effect of DHEA on body weight gainWe performed two experimental groups: rats (5-6 weeks old), and mice (3 weeks old). Both groups received either the HU21 peptide in the diet or vehicle, and we recorded weight gain on day 0, as well as on day 6, prior to injection of any test compound. For this purpose we took body weights of 12-30 rats and 6-8 mice after 6 weeks of administration of the aqueous solution of HU21. A comparison of the body weights of the groups receiving HU21 and vehicle, and controls, revealed that HU21 treatment (but not vehicle) is associated with a significant increase in body weight gain when compared with controls. In particular this increase is greater in the groups receiving HU21 vs vehicle at day 6. These results suggest that HU21 may play a role in inducing anabolic steroid-induced muscle hypertrophy.Effect of DHEA on muscle weight gainTo compare the effects of diet and HU21 injection, we studied body weight and leg length (Ll). We found that DHEA was associated with an increased Ll, while only with a decrease with a low DHEA dose (10-20 ng/kg).Effect of DHEA on muscle massTo compare the effects of diet and DHEA injection, we performed the following experiments: first we studied body length and head circumference (Hlc), and then we looked at body mass. As a reference body length for our rat studies, a similar effect of DHEA was observed in the rodent literature. Thus, DHEA may be effective in reducing muscle mass in the rats, but it is not likely to have a major role as an anabolic steroid in humans.Effect of DHEA on body weight and LcAs described above, DHEA was significantly associated with an increase in body weight gain and a decrease in body weight (Lc) with no significant interactions between diet and dose nor between dose and body weight.Effect of DHEA on Lc in miceThis experiment was conducted as an experimental comparison between doses of DHEA 1 and 20 ng/kg in the diet. These levels are approximately the highest doses of DHEA reported to increase Lc.Similar articles: